- dry mouth,
- loss of appetite,
- increased sweating,
- blurred vision, – You may think your eyesight needs correction.
- rash, or itching may occur.
Unlikely but serious side effects:
- unusual or severe mental/mood changes (e.g., anxiety, mania),
- weight loss,
- change in sexual desire and ability,
- uncontrolled movements (tremor),
- difficulty urinating.
Rare but very serious side effects:
- chest pain,
- stomach pain,
- black stools,
- vomit that looks like coffee grounds,
- easy bruising/bleeding,
- unusual bleeding,
This medication should not be used if you have certain medical conditions.
- severe kidney disease,
- glaucoma (uncontrolled narrow-angle).
- other mental/mood disorders (e.g., bipolar disorder, mania),
- liver disease,
- kidney disease,
- stomach problems (e.g., bleeding or slow stomach emptying),
- drug or alcohol abuse,
- seizure disorder.
- dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery.
- If you are pregnant, this medication should be used only when clearly needed during the first 6 months of pregnancy.
- Due to possible complications to an infant at birth, this medicine is not recommended for use during the last 3 months of pregnancy.
- Breast-feeding while taking this drug is not recommended.
suicidal thoughts, worsening depression, or any other mental/mood changes, including new or worsening anxiety, agitation, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, rapid speech.
Certain medications taken with this product could result in serious, possibly fatal, drug interactions.
- Avoid taking drugs called MAO inhibitors
(e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) with or within 2 weeks of starting duloxetine or at least 5 days after stopping it.
- certain drugs used to treat abnormal heart rhythms (e.g., propafenone, flecainide, quinidine),
- certain SSRI anti-depressants (fluoxetine, fluvoxamine, paroxetine),
- other drugs which can cause bleeding/bruising (e.g., thrombolytic drugs such as TPA,
- anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen).
- Low-dose aspirin (usually 81-325 mg per day) for heart attack or stroke prevention should be continued unless your doctor instructs you otherwise. Aspirin is similar to NSAID drugs, and can increase the risk of bleeding in combination with this medication.
- drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., carbamazepine),
- medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers.